# Type I collagen
## Type III collagen
*Compared to a leading hyaluronic acid dermal filler
** At 3 months post-injection compared to baseline
^At month 7 compared to month 4
1.Yutskovskaya et al. “A randomized, split-face, histomorphologic study comparing a volumetric calcium hydroxylapatite and a hyaluronic acid-based dermal filler.” Journal of drugs in dermatology: JDD 13.9 (2014): 1047-1052.
2.Silvers SL et al. Prospective, Open-Label, 18-Month Trial of Calcium Hydroxylapatite (RADIESSE) for Facial Soft-Tissue Augmentation in Patients with Human Immunodeficiency Virus–Associated Lipoatrophy: One-Year Durability Plast. Reconstr. Surg. 2006; 118: p34.
3.Casabona et al. “Microfocused ultrasound with visualization and calcium hydroxylapatite for improving skin laxity and cellulite appearance.” Plastic and Reconstructive Surgery Global Open 5.7 (2017).
4.Yutskovskaya et al. “Improved neocollagenesis and skin mechanical properties after injection of diluted calcium hydroxylapatite in the neck and décolletage: a pilot study.” Journal of drugs in dermatology: JDD 16.1 (2017): 68-74.
5.Ultherapy increases collagen synthesis by 42%.-Ulthera data on file
Please note that above information hasn’t include any direct comparison between different fillers and are indirectly derived from the cited reference.
The above information is provided to you in response to your prior unsolicited, individual inquiry for medical/scientific informational purposes only. Merz Asia Pacific Pte Ltd and its affiliates do not support the use of its product/s in any other manner or indication as set forth in the marketing authorization of the product/s. Healthcare Professionals should weigh the risks and benefits of treatment and determine its appropriateness as a case by case basis.
*资料来源：https://www.beautykol.com.hk/
^Shuster S, Black MM, McVitie E. The influence of age and sex on skin thickness, skin collagen and density. Br J Dermatol. 1975;93:639-643.
